Canine Leucocyte Adhesion Deficiency (CLAD) is an hereditary condition that can effect Irish Setters and results in early death to affected puppies. It is caused by a single recessive mutation in a gene that controls the function of white blood cells and results in immunodeficiency. Thankfully, research carried out at the University of Uppsala in Sweden has resulted in the development of a DNA test to identify Irish Setters that carry the mutant gene.
The Irish Setter Breed Clubs in the UK have agreed with the Kennel Club to follow a breeding control scheme to try to eradicate CLAD within the Irish Setter population. The outline of the scheme is as follows:-
From July 1st 2000 all Irish Setters used for breeding should be either hereditarily clear of CLAD or have a CLAD DNA test before they are used for breeding.
Identified carriers can be used for breeding, but they should only be mated to a dog that is either hereditarily clear of CLAD or one that has DNA tested clear of CLAD; carriers should not be mated to carriers.
All of the registered offspring of a carrier mated to a clear should be clearly identified, DNA tested and registered as either tested clear or carrier.
From 1st July 2005 the Kennel Club will only register Irish Setters that are proven clear of the CLAD mutation, either by direct DNA testing or by virtue of having parents that are proven to be clear of the CLAD mutation (i.e. hereditarily clear)
No carriers will be registered after June 30th 2005.
The results of CLAD DNA tests that have been carried out on Irish Setters are recorded by the Kennel Club and may viewed on The Kennel Club website but to obtain access you will need to have registered as a user and log in to the site once logged in the pages are:-
Irish Setters tested CLEAR of CLAD www.thekennelclub.org.uk/cgi-bin/library.cgi?action=detail&id=3106
Irish Setter CLAD Carriers www.thekennelclub.org.uk/cgi-bin/library.cgi?action=detail&id=3107
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